A circulating myocardial depressant substance in septic shock.
نویسنده
چکیده
منابع مشابه
Hemofiltration and left ventricular function in sepsis: mechanisms and clinical implications.
Over the last decade, it became clear that left ventricular (LV) dysfunction is typical of animal and human septic shock [1]. Circulating myocardial depressant substances [2] and local release of mediators [3], rather than global myocardial hypoperfusion [4,5], seem responsible for this phenomenon. Indeed, a series of reports [3] by Parrillo et al. in the 1980s were able to conclusively link le...
متن کاملA circulating myocardial depressant substance is associated with cardiac dysfunction and peripheral hypoperfusion (lactic acidemia) in patients with septic shock.
Using spontaneously beating rat myocardial cells as an in vitro model of myocardial depression, recent studies demonstrated that septic shock patients' sera frequently contain a myocardial depressant substance (MDS) that is associated with a reversible decrease in left ventricular ejection fraction (LVEF). To further characterize MDS, 50 consecutive patients with possible septic shock were stud...
متن کاملA Circulating Myocardial Depressant Substance in Humans with Septic Shock
We have previously described a subpopulation of patients with septic shock who had a reversible depression of radionuclidedetermined left ventricular ejection fraction (EF). To investigate the mechanism of this myocardial depression, an in vitro model of mammalian myocardial cell performance was established employing primary spontaneously beating rat myocardial cells. The contraction of a singl...
متن کاملA circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance.
We have previously described a subpopulation of patients with septic shock who had a reversible depression of radionuclide-determined left ventricular ejection fraction (EF). To investigate the mechanism of this myocardial depression, an in vitro model of mammalian myocardial cell performance was established employing primary spontaneously beating rat myocardial cells. The contraction of a sing...
متن کاملTumor Necrosis Factor et and Interleukin 1~ Are Responsible for In Vitro Myocardial Cell Depression Induced by Human Septic Shock Serum
Previous studies have demonstrated the presence of myocardial depression in clinical and experimental septic shock. This depression is associated with the presence of a circulating myocardial depressant substance with physical characteristics consistent with cytokines. The present study utilized an in vitro myocardial cell assay to examine the role of various human recombinant cytokines, includ...
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ورودعنوان ژورنال:
- Chest
دوره 97 6 شماره
صفحات -
تاریخ انتشار 1990